Zhejiang senlong technology(expird)
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CAS NO.541-16-2
98%(1-500)Kilogram98%(500-1000)Kilogram
1.Professional synthesis laboratory and production base.
2.Strong synthesis team and service team.
3.Professional data management system.
4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/GC,MS,COA,SDS
5.(2000+Suppliers) Partners.Any inquiries will be replied within 24 hours.
6.Rich shipping methods,ex. Fedex,DHL,TNT,BY SEA and BY AIR.
7.Shipping information includes Commerical Invoice,Packing List,COA,Invoice,BSE/TSE.If your markets have any special requirements, please let us know.
8.We can accept various payment methods,L/C,T/T, etc.
9.Professional packaging can be according the customers’requirment.
10.Product application: Medicinal Chemistry 、 Biomedicine、 Pharmaceutical intermediate、 Chemistry experiment 、Biological experiments 、Chemical reagent、 For R&D use only.
Product Properties
| Di-tert-Butyl malonate Chemical Properties | |
| Cas No. | 541-16-2 |
| Molecular Formula | C11H20O4 |
| Molecular Weight | 216.27 |
| Synonyms | Propanedioic acid, bis(1,1-dimethylethyl) ester;propanedioicacid,bis(1,1-dimethylethyl)ester;Di-tert-butyl malonate stab. with potassium carbonate;Di-tert-Butyl malote;1,3-di-tert-butyl propanedioate;DI-TERT-BUTYL MALONATE;DI-T-BUTYL MALONATE;bis(1,1-dimethylethyl) malonate |
| Melting point | -7--6 °C (lit.) |
| Boiling point | 110-111 °C/22 mmHg (lit.) |
| Density | 1.0±0.1 g/cm3 |
| Refractive Index | n20/D 1.418(lit.) |
| Fp | 88 °C |
| Storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Solubility | Chloroform, Ethyl Acetate |
| pka | 11.87±0.46(Predicted) |
| Form | Liquid |
| Color | Clear colorless to slightly yellow |
| Water Solubility | It is hardly soluble in water. |
| Merck | 143,034 |
| BRN | 1781766 |
| InChIKey | CLPHAYNBNTVRDI-UHFFFAOYSA-N |
| CAS DataBase Reference | 541-16-2(CAS DataBase Reference) |
| NIST Chemistry Reference | di-tert-Butyl malonate(541-16-2) |
| EPA Substance Registry System | Propanedioic acid, bis(1,1-dimethylethyl) ester (541-16-2) |
Di-tert-Butyl malonate Usage
1. In the preparation of ketones.
2. Di-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T
3. Di-tert-butyl malonate was used in total synthesis of (+/?)-actinophyllic acid. It was also employed as precursor for metal-organic chemical vapor deposition of HfO2 and ZrO2 thin films.
Product Preparation
The central step in these syntheses is the aza-Cope/Mannich reaction, which constructs the previously unknown hexacyclic ring system of actinophyllic acid in one step from much simpler tetracyclic precursors. The tetracyclic hexahydro-1,5-methano-1H-azocino[4,3-b]indole ketone rac-37 is assembled from o-nitrophenylacetic acid in four steps, with oxidative cyclization of a dienolate derivative of tricyclic precursor rac-35 being the central step. In the first-generation synthesis, this intermediate is transformed in two steps to homoallyl amine rac-43, whose formaldiminium derivative undergoes efficient aza-Cope/Mannich reaction to give pentacyclic ketone rac-44. In four additional steps, this intermediate is advanced to (+/-)-actinophyllic acid. The synthesis is streamlined by elaborating ketone rac-37 to beta-hydroxyester intermediate rac-53, which is directly transformed to (+/-)-actinophyllic acid upon exposure to HCl and paraformaldehyde. This concise second-generation total synthesis of (+/-)-actinophyllic acid is realized in 22% overall yield from commercially available di-tert-butyl malonate and o-nitrophenylacetic acid by a sequence that proceeds by way of only six isolated intermediates. The first enantioselective total synthesis of (-)-actinophyllic acid (1) is accomplished by this direct sequence from tricyclic keto malonate (S)-35. Catalytic enantioselective reduction of alpha,beta-unsaturated ketone 66 is the key step in the preparation of intermediate (S)-35 from the commercially available Boc-amino acid 65. Discussed also is the possibility that the aza-Cope/Mannich reaction might be involved in the biosynthesis of (-)-actinophyllic acid.
Company Information
We Zhejiang Senlong Technology Co., Ltd located in Zhicheng industrial park ,Changxing ,Zhejiang, China. We focus on creating a professional operation team with a sound organizational structure which includes more than 20 professional employees. Moreover, more than 90% of staffs have a bachelor's degree or above, and generally have biopharmaceutical education or work background in the chemical industry, which builds a solid foundation for providing professional and efficient services in the pharmaceutical industry.
We have independent QA department to perform pre-audit, supporting regulations and registration. We provide valuable references for customers to select high-quality suppliers at early stage, provide professional corrections to suppliers, aiming to improve the quality system and avoid any surprise in future. Meanwhile, in order to enhance the professional capabilities, we often provide training staffs about regulations and quality systems for better supporting customers.
Senlong has established very good cooperation and business relations with hundreds of qualified manufacturers worldwide. Our products were exported to more than 15 countries.